Yes, it handles more than just AppImages. You can install, remove, and update them automatically, both systemwide and locally.

Linked project: VirtualBox KVM appimage https://github.com/ivan-hc/VirtualBox-appimage

This is a portable version of VirtualBox that uses KVM as the hypervisor instead of vboxdrv.

Original project: https://github.com/cyberus-technology/virtualbox-kvm

Unfortunately, it's a bit outdated as of February 7, 2025, but it combines the best features from both KVM and VirtualBox worlds.

Another great project is Conty https://github.com/Kron4ek/Conty.

It’s an easy-to-use compressed unprivileged Linux container packed into a single executable. In other words, it's a portable ArchLinux that contains various applications such as Wine, Bottles, PlayOnLinux, Lutris, etc., along with all necessary libraries. The apps can also be run sandboxed using bubblewrap.

The image includes systemd as a dependency, but not as the init system. It can be recreated manually with a different set of software.